Oxidative Stress and Aging
نویسندگان
چکیده
-----------------------------------------------------------------------------------------------3 Introduction--------------------------------------------------------------------------------------------4 Main text: Reactive oxygen species ----------------------------------------------------------------------4 Antioxidant defenses---------------------------------------------------------------------------6 Oxidative damage of cellular macromolecules in aging----------------------------------7 Lipid -----------------------------------------------------------------------------------8 Protein----------------------------------------------------------------------------------8 DNA------------------------------------------------------------------------------------9 Oxidants in cellular signaling and aging---------------------------------------------------10 Therapeutic strategies against aging--------------------------------------------------------11 Caloric restriction---------------------------------------------------------------------12 Antioxidant supplement--------------------------------------------------------------13 Proposal of future study----------------------------------------------------------------------15 Hypothesis------------------------------------------------------------------------------15 Specific aim 1---------------------------------------------------------------------------17 Specific aim 2---------------------------------------------------------------------------18 Conclusion---------------------------------------------------------------------------------------------18 References---------------------------------------------------------------------------------------------20
منابع مشابه
The relationship between Indicators of plasma oxidative stress and photo aging
Introduction: Photo aging is significantly different from chronological aging in both clinical and histological appearances. It has been suggested that oxidative stress generated by ultraviolet radiation (UVR), leads to photo aging over a long time period. This study was conducted to determine the relationship between the indicators of plasma oxidative stress and photo damaged skin in patient...
متن کاملIs sub-chronic exercise in Combination with medicinal nanoparticles a protective strategy against Doxorubicin-induced Hepatic oxidative stress and apoptosis in aging model rats?
Objective(s): Oxidative stress and apoptosis are the major side effects of doxorubicin (DOX) and the advantages accruing fromexercise and some medicinal herbs in mitigation of these toxic side effects is well documented. But so far, the effects of exercise in combination with medicinal nanoparticles on oxidative stress and apoptosis signaling simultaneously, in liver tissue are unknown. Hence, ...
متن کاملProtective effect of crocin against d-galactose-induced aging in mice
Objective: Aging is a multifactorial phenomenon, which attribute to different diseases and abnormalities in living systems. Oxidative stress, which is an important factor in aging, exacerbates this process via different mechanisms. Crocin (CR), one of the active components of saffron showed strong antioxidant effects. In the present study, anti-aging property of crocin was investigated in mice....
متن کاملEvaluation of Oxidative Stress and DNA Damage Indicators Following A Long Period of Resistance Training in Sedentary Older Men
Background and Aim: Excessive production of free radicals and the accumulation of oxidative damages play an important role in accelerating the aging process. However, one of the ways to fight against aging and related diseases is through physical activity. The aim of the present study was to investigate the effect of 12 weeks of resistance training on oxidative stress indicators (8-iso-prostagl...
متن کاملAge related changes in indices of bone metabolism and oxidative stress in Postmenopausal women in Southern Nigeria
Background and Objectives: Oxidative stress (OS) associated with estrogen deficiency in menopause has been implicated in various complications of menopause. Some indices of OS, bone metabolism, and uric acid (UA) in postmenopausal women were assessed as possible predictors of gouty osteoarthritis. Materials and Methods: This case-control study enrolled 40 postmenopausal women and 60 premenopau...
متن کاملOxidative Stress and Human Disease: a Review
Background: The human body needs both types of oxidants (free radicals) and antioxidants for normal metabolism, signal transduction mechanism, and the order of cellular activity. Free radicals can be either harmful or helpful to the body, in fact, they play a dual role as both toxic and beneficial compounds. The human body has the natural antioxidant defense mechanism to counteract the free rad...
متن کامل